Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal to take our company’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Discovery Biologics in Boston, MA is seeking a Senior Scientist to join our Protein Analytics group and expand our capabilities to engineer and characterize novel biologics and cell therapies. The group is responsible for developing and leveraging novel biophysical techniques to characterize a diverse portfolio of biologics, including monoclonal antibodies, bi/multi-specifics, Fc-fusion proteins and other novel protein therapeutics. The Protein Analytics group is part of the Discovery Biologics organization which uses machine learning, advanced automation, ultra-high throughput in vitro and in vivo technologies, and state-of-the-art characterization techniques to discover and engineer biologics.

In this role, the successful candidate will directly contribute to the invention of novel biologics and will be responsible for the detailed analytical characterization of early drug candidates using liquid chromatography-based methods (SEC, RP, HIC), light scattering (SEC-MALS, DLS), thermal stability (DSF), capillary electrophoresis-based methods (CE-SDS) and mass spectrometry. Using their deep expertise in analytical method development, high throughput execution, and the application of new technologies, they will enable the discovery and engineering of biologics. As part of project teams, they will collaborate across groups to solve complex problems in disease biology and drug discovery. They will attend scientific conferences, contribute to publications, and help to set the group strategy. The successful candidate will join a diverse group of innovative scientists and engineers that are driving the next revolution in biologics discovery and engineering.

We recognize that the diversity in our team is our strength and are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission.

Responsibilities:

• In support of program priorities, carry out detailed analytical characterization of early drug candidates using liquid chromatography-based methods (SEC, RP, HIC), light scattering (SEC-MALS, DLS), thermal stability (DSF), capillary electrophoresis-based methods (CE-SDS) and mass spectrometry

• Present research findings at group meetings, project meetings, and at external meetings

• Contribute to program strategy as a characterization representative on project teams

• Collaborate with team members to expand characterization and developability workflows for analysis and optimization of lead biologic molecules

• Actively develop talent, strategically maximize diversity to complement and strengthen our team

• Foster a high-performance culture of collaboration, engagement, self-accountability and inclusion

• Contribute to and lead the authoring of patents and external publications

Qualifications and Experience:

• PhD in Biochemistry, Analytical Chemistry, Synthetic Biology, Bioengineering, or a related discipline with 0+ years of relevant experience or MS degree with 5+ years of relevant industry experience OR BS with 8+ years of experience

• Broad experience in biophysical characterization and analytical techniques

• Expertise in analytical method development, high throughput execution, and the application of new technologies

Required skills:

• Hands on experience with LC/MS techniques for detailed characterization of biologics including mass determination, glycan-analysis, peptide mapping, and characterization of post-translational modifications.

• Deep expertise in analytical characterization of proteins using LC based methods including SEC, reverse phase , and hydrophobic interaction chromatography (HIC), including method development, validation and execution to support fast paced biologics discovery.

• Demonstrated ability to work in a collaborative multi-disciplinary team environment.

• Excellent communication and organizational skills.

Preferred skills

• Experience with light scattering (SEC-MALS, DLS), thermal stability (DSF), and capillary electrophoresis-based methods (CE-SDS)

• Experience developing microfluidics, lab-on-a-chip, or flow-based research.

• Fluency in a modern programming language such as C++, Python, or similar.

• Experience will laboratory automation such as Tecan, Biomek, Hamilton, or similar.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

#EligibleforERP

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

OEB4, potent chemicals and biologics

Job Posting End Date:

08/30/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.